GABAA Receptors, Anesthetics and Anticonvulsants in Brain Development
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چکیده
منابع مشابه
Functional sites for anesthetics in GABAA receptors
A key target for the intravenous anesthetics propofol and etomidate is the γ-aminobutyric acid type A (GABAA) receptor [1]. GABAA receptors are the most important inhibitory neurotransmitter receptors in the central nervous system. They are composed of five subunits that surround a central Clselective ion channel. Each subunit has an extracellular domain, four trans-membrane domains, and a vari...
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1. The loop diuretic furosemide is known to antagonize the function of gamma-aminobutyric acid type A (GABAA) receptors. The purpose of the present study was to examine the direct interaction of furosemide with the GABAA receptors by autoradiography and ligand binding studies with native rat and human receptors and with recombinant receptors composed of rat subunits. 2. Autoradiography with [35...
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Modulation of the A type γ-aminobutyric acid receptors (GABAAR) is one of the major drug targets for neurological and psychological diseases. The natural flavonoid compound luteolin (2-(3,4-Dihydroxyphenyl)- 5,7-dihydroxy-4-chromenone) has been reported to have antidepressant, antinociceptive, and anxiolytic-like effects, which possibly involve the mechanisms of modulating GABA signaling. Howev...
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............................................................................................................................. 7 ORIGINAL COMMUNICATIONS ......................................................................................... 8 ABBREVIATIONS................................................................................................................... 9
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GABA(A) receptors have an age-adapted function in the brain. During early development, they mediate excitatory effects resulting in activation of calcium sensitive signaling processes that are important for the differentiation of the brain. In more mature stages of development and in adults, GABA(A) receptors transmit inhibitory signals. The maturation of GABA(A) signaling follows sex-specific ...
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ژورنال
عنوان ژورنال: CNS & Neurological Disorders - Drug Targets
سال: 2008
ISSN: 1871-5273
DOI: 10.2174/187152708784083812